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Figure: Effect of hAb21 mAb on tumor growth in knock-in mice expressing human PD-1 （Human PD-1 gene knock-in mice were inoculated with 1x106 syngeneic MC38 tumor cells. When tumors reached 50 mm3 in size，mice were randomized into 3 groups. Intra-peritoneal (i.p) injections with 200 ug mAb (pembrolizumab or hAb21) or saline were given on days 6, 10, 13 and 17 after inoculation. A: Tumor growth in early-stage; B: Tumor growth in both early- and later-stage）.
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